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Issue 76, 2017
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Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

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Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA–protein interactions triggered by the PS2 moiety.

Graphical abstract: Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

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Article information


Submitted
23 Jul 2017
Accepted
28 Aug 2017
First published
29 Aug 2017

Chem. Commun., 2017,53, 10508-10511
Article type
Communication

Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

X. Yang, N. Dinuka Abeydeera, F. Liu and M. Egli, Chem. Commun., 2017, 53, 10508
DOI: 10.1039/C7CC05722A

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