Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 65, 2017
Previous Article Next Article

A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

Author affiliations

Abstract

A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system is reported. An allylation/cross-coupling process of a haloaryl aldehyde, an aryl BPin, and an allyl BPin can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C–C bond formations without intervention. This process offers efficient access to an array of functionalised products including pharmaceutical and natural product scaffolds.

Graphical abstract: A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

Back to tab navigation

Supplementary files

Article information


Submitted
13 Jul 2017
Accepted
26 Jul 2017
First published
26 Jul 2017

Chem. Commun., 2017,53, 9139-9142
Article type
Communication

A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

C. Xu, J. W. B. Fyfe, C. P. Seath, S. H. Bennett and A. J. B. Watson, Chem. Commun., 2017, 53, 9139
DOI: 10.1039/C7CC05416E

Social activity

Search articles by author

Spotlight

Advertisements