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Issue 71, 2017
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Nucleophilic trifluoromethylation of electron-deficient arenes

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Abstract

A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion of nitroarenes into 1,2-trifluoromethylated nitroarenes, via a C–H activation pathway. Furthermore, a substitution of nitroarenes to trifluoromethyl arenes is also presented.

Graphical abstract: Nucleophilic trifluoromethylation of electron-deficient arenes

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Publication details

The article was received on 13 Jul 2017, accepted on 14 Aug 2017 and first published on 14 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05415G
Chem. Commun., 2017,53, 9858-9861

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    Nucleophilic trifluoromethylation of electron-deficient arenes

    J. A. Pike and J. W. Walton, Chem. Commun., 2017, 53, 9858
    DOI: 10.1039/C7CC05415G

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