RhIII-Catalyzed site-selective amidation with nitrone as a traceless directing group: an approach to functionalized arylaldehydes

Hong Deng; Hongji Li; Wenge Zhang; Lei Wang

doi:10.1039/C7CC05297A

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Rh^III-Catalyzed site-selective amidation with nitrone as a traceless directing group: an approach to functionalized arylaldehydes†

Hong Deng,^a Hongji Li,

*^a Wenge Zhang^a and Lei Wang

*^ab

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* Corresponding authors

^a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: hongjili@chnu.edu.cn, leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032, P. R. China

Abstract

An efficient Rh-catalyzed site-selective amidation of nitrones with 1,4,2-dioxazol-5-ones has been developed. The reaction can tolerate a number of groups and generates functionalized aldehydes in good yields. The significance of the amidation is highlighted by the late-stage transformation of the formed aldehydes.

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Article information

DOI: https://doi.org/10.1039/C7CC05297A
Article type: Communication
Submitted: 09 Jul 2017
Accepted: 29 Aug 2017
First published: 29 Aug 2017

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Chem. Commun., 2017,53, 10322-10325

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Rh^III-Catalyzed site-selective amidation with nitrone as a traceless directing group: an approach to functionalized arylaldehydes

H. Deng, H. Li, W. Zhang and L. Wang, Chem. Commun., 2017, 53, 10322 DOI: 10.1039/C7CC05297A

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