Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 60, 2017
Previous Article Next Article

Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

Author affiliations

Abstract

Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases. Despite their potential therapeutic value, there are no suitably protected ALE building blocks reported in the literature to enable their site-specific incorporation into synthetic peptides. The synthesis of an Fmoc-protected ALE building block, Nāˆˆ-(3-methylpyridinium)lysine (MP-lysine) and its incorporation into collagen model peptides is reported.

Graphical abstract: Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jun 2017, accepted on 06 Jul 2017 and first published on 06 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC05025A
Chem. Commun., 2017,53, 8459-8462

  •   Request permissions

    Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

    I. Kavianinia, S. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks and M. A. Brimble, Chem. Commun., 2017, 53, 8459
    DOI: 10.1039/C7CC05025A

Search articles by author

Spotlight

Advertisements