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Issue 68, 2017
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Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

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Abstract

A facile method for the preparation of antibody–quantum dot (QD) conjugates using the immunoglobulin binding (B1) domain of protein G is presented. The utility of antibody–QD conjugates using the B1 domain is demonstrated for fluorescence imaging of breast tumor cells in vitro and in vivo.

Graphical abstract: Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

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Article information


Submitted
27 Jun 2017
Accepted
31 Jul 2017
First published
02 Aug 2017

Chem. Commun., 2017,53, 9450-9453
Article type
Communication

Immunoglobulin binding (B1) domain mediated antibody conjugation to quantum dots for in vitro and in vivo molecular imaging

S. Tsuboi, A. Sasaki, T. Sakata, H. Yasuda and T. Jin, Chem. Commun., 2017, 53, 9450
DOI: 10.1039/C7CC04966H

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