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Issue 58, 2017
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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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Abstract

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

Graphical abstract: Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

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Submitted
20 Jun 2017
Accepted
30 Jun 2017
First published
30 Jun 2017

Chem. Commun., 2017,53, 8231-8234
Article type
Communication

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

M. Kamal Masud, Md. N. Islam, Md. H. Haque, S. Tanaka, V. Gopalan, G. Alici, N. Nguyen, A. K. Lam, Md. S. A. Hossain, Y. Yamauchi and M. J. A. Shiddiky, Chem. Commun., 2017, 53, 8231
DOI: 10.1039/C7CC04789D

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