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Issue 62, 2017
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Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

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Abstract

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.

Graphical abstract: Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

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Supplementary files

Article information


Submitted
05 Jun 2017
Accepted
10 Jul 2017
First published
10 Jul 2017

Chem. Commun., 2017,53, 8671-8674
Article type
Communication

Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

Y. Zhou, Z. Di, X. Li, Y. Shan, W. Li, H. Zhang and Y. Xiao, Chem. Commun., 2017, 53, 8671
DOI: 10.1039/C7CC04345G

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