Issue 62, 2017
From the journal:

Chemical Communications

Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells†

Yiqing Zhou, ORCID logo a   Zhengao Di,a   Xiaoming Li,bc   Yuanhong Shan,d   Weichao Li,a   Haibing Zhangb  and  Youli Xiao ORCID logo *acd  

* Corresponding authors

a CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
E-mail: ylxiao@sibs.ac.cn

b Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

c University of Chinese Academy of Sciences, Beijing, China

d Core Facility Centre of the Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.

Graphical abstract: Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

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Article information

DOI
https://doi.org/10.1039/C7CC04345G
Article type
Communication
Submitted
05 Jun 2017
Accepted
10 Jul 2017
First published
10 Jul 2017

Chem. Commun., 2017,53, 8671-8674

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Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

Y. Zhou, Z. Di, X. Li, Y. Shan, W. Li, H. Zhang and Y. Xiao, Chem. Commun., 2017, 53, 8671 DOI: 10.1039/C7CC04345G

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