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Issue 65, 2017
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Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition

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Abstract

We present herein a new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones. Both experimental and DFT studies revealed that this Ag-catalyzed unusual transformation is initiated by a facile aza-Michael addition instead of the conventional imine condensation. This catalytic method enables an efficient synthesis of polysubstituted pyrroles.

Graphical abstract: Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition

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Article information


Submitted
08 May 2017
Accepted
09 Jun 2017
First published
09 Jun 2017

Chem. Commun., 2017,53, 9067-9070
Article type
Communication

Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition

J. Liao, W. J. Yap, J. Wu, M. W. Wong and Y. Zhao, Chem. Commun., 2017, 53, 9067
DOI: 10.1039/C7CC03468G

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