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Issue 44, 2017
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Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy

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Abstract

The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species. These characteristic features make the taurine-modified Ru-complex a potentially effective photosensitizer for PDT of target cancer cells, with outstanding efficacy in cancerous brain cells.

Graphical abstract: Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy

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Supplementary files

Article information


Submitted
29 Apr 2017
Accepted
08 May 2017
First published
08 May 2017

Chem. Commun., 2017,53, 6033-6036
Article type
Communication

Taurine-modified Ru(II)-complex targets cancerous brain cells for photodynamic therapy

E. Du, X. Hu, S. Roy, P. Wang, K. Deasy, T. Mochizuki and Y. Zhang, Chem. Commun., 2017, 53, 6033
DOI: 10.1039/C7CC03337K

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