Issue 58, 2017
From the journal:

Chemical Communications

New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells†

Parikshit Moitra, ORCID logo ‡a   Krishan Kumar,§a   Sourav Sarkar,b   Paturu Kondaiah,c   Wei Duand  and  Santanu Bhattacharya ORCID logo ‡*abe  

* Corresponding authors

a Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India
E-mail: sb23in@yahoo.com
Fax: +91-80-2360-0529
Tel: +91-80-2293-2664

b Director's Research Unit, Indian Association for the Cultivation of Science, Kolkata 700032, India

c Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India

d School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3216, Australia

e Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India

Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

Graphical abstract: New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

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Article information

DOI
https://doi.org/10.1039/C7CC03320F
Article type
Communication
Submitted
28 Apr 2017
Accepted
17 Jun 2017
First published
26 Jun 2017

Chem. Commun., 2017,53, 8184-8187

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New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

P. Moitra, K. Kumar, S. Sarkar, P. Kondaiah, W. Duan and S. Bhattacharya, Chem. Commun., 2017, 53, 8184 DOI: 10.1039/C7CC03320F

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