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Issue 58, 2017
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New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

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Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

Graphical abstract: New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

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Supplementary files

Article information


Submitted
28 Apr 2017
Accepted
17 Jun 2017
First published
26 Jun 2017

Chem. Commun., 2017,53, 8184-8187
Article type
Communication

New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

P. Moitra, K. Kumar, S. Sarkar, P. Kondaiah, W. Duan and S. Bhattacharya, Chem. Commun., 2017, 53, 8184
DOI: 10.1039/C7CC03320F

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