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Issue 65, 2017
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Redox-responsive xanthene–coumarin–chlorambucil-based FRET-guided theranostics for “activatable” combination therapy with real-time monitoring

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Abstract

A FRET donor–acceptor xanthene–coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The “locked” FRET pair was selectively “unlocked” by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.

Graphical abstract: Redox-responsive xanthene–coumarin–chlorambucil-based FRET-guided theranostics for “activatable” combination therapy with real-time monitoring

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Supplementary files

Article information


Submitted
26 Apr 2017
Accepted
25 Jul 2017
First published
25 Jul 2017

Chem. Commun., 2017,53, 9109-9112
Article type
Communication

Redox-responsive xanthene–coumarin–chlorambucil-based FRET-guided theranostics for “activatable” combination therapy with real-time monitoring

M. Gangopadhyay, R. Mengji, A. Paul, Y. Venkatesh, V. Vangala, A. Jana and N. D. P. Singh, Chem. Commun., 2017, 53, 9109
DOI: 10.1039/C7CC03241B

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