A series of double-fluorogenic siliconrhodamine probes were synthesized. These tetrazine-functionalized, membrane-permeable labels allowed site-specific bioorthogonal tagging of genetically manipulated intracellular proteins and subsequent imaging using super-resolution microscopy.
E. Kozma, G. Estrada Girona, G. Paci, E. A. Lemke and P. Kele, Chem. Commun., 2017, 53, 6696 DOI: 10.1039/C7CC02212C
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