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Issue 40, 2017
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Peptide array functionalization via the Ugi four-component reaction

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Abstract

The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.

Graphical abstract: Peptide array functionalization via the Ugi four-component reaction

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Article information


Submitted
14 Mar 2017
Accepted
02 May 2017
First published
02 May 2017

Chem. Commun., 2017,53, 5553-5556
Article type
Communication

Peptide array functionalization via the Ugi four-component reaction

B. Ridder, D. S. Mattes, A. Nesterov-Mueller, F. Breitling and M. A. R. Meier, Chem. Commun., 2017, 53, 5553
DOI: 10.1039/C7CC01945A

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