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Issue 38, 2017
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From [11C]CO2 to [11C]amides: a rapid one-pot synthesis via the Mitsunobu reaction

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Abstract

A novel amide synthesis methodology is described using amines, CO2 and Grignard reagents and Mitsunobu reagents. The method was applied to carbon-11 radiochemistry to label amides using cyclotron-produced [11C]CO2. The synthetic utility of the one-pot labelling methodology was demonstrated by producing [11C]melatonin. The incorporation of [11C]CO2 into [11C]melatonin was 36% – determined by radioHPLC 2 min post [11C]CO2 delivery.

Graphical abstract: From [11C]CO2 to [11C]amides: a rapid one-pot synthesis via the Mitsunobu reaction

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Publication details

The article was received on 22 Feb 2017, accepted on 24 Mar 2017 and first published on 27 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01407D
Citation: Chem. Commun., 2017,53, 5334-5337
  • Open access: Creative Commons BY license
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    From [11C]CO2 to [11C]amides: a rapid one-pot synthesis via the Mitsunobu reaction

    S. Bongarzone, A. Runser, C. Taddei, A. K. H. Dheere and A. D. Gee, Chem. Commun., 2017, 53, 5334
    DOI: 10.1039/C7CC01407D

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