Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 28, 2017
Previous Article Next Article

Palladium-catalyzed regioselective C–H fluoroalkylation of indoles at the C4-position

Author affiliations

Abstract

An exclusive catalytic C4-selective fluoroalkylation of indoles with highly active (1H, 1H-perfluoroalkyl)mesityliodonium triflate has been described. The key to its high regioselectivity is the appropriate choice of an easily accessible, cheap and removable directing group at the C3 position in the presence of a Pd(OAc)2 catalyst. Besides indole fluoroalkylation, the application of this strategy in other heteroarenes such as benzo[b]thiophene is also described.

Graphical abstract: Palladium-catalyzed regioselective C–H fluoroalkylation of indoles at the C4-position

Back to tab navigation

Supplementary files

Article information


Submitted
17 Feb 2017
Accepted
06 Mar 2017
First published
06 Mar 2017

Chem. Commun., 2017,53, 3945-3948
Article type
Communication

Palladium-catalyzed regioselective C–H fluoroalkylation of indoles at the C4-position

A. J. Borah and Z. Shi, Chem. Commun., 2017, 53, 3945
DOI: 10.1039/C7CC01274H

Social activity

Search articles by author

Spotlight

Advertisements