Facile synthesis of chlorin bioconjugates by a series of click reactions

Junior Gonzales; N. V. S. Dinesh K. Bhupathiraju; William Perea; Huong Chu; Naxhije Berisha; Veronica Bueno; Naser Dodic; Julia Rozenberg; Nancy L. Greenbaum; Charles Michael Drain

doi:10.1039/C7CC01265A

Facile synthesis of chlorin bioconjugates by a series of click reactions†

Junior Gonzales,^ab N. V. S. Dinesh K. Bhupathiraju,^a William Perea,^a Huong Chu,^ab Naxhije Berisha,^a Veronica Bueno,^a Naser Dodic,

^a Julia Rozenberg,^a Nancy L. Greenbaum^ab and Charles Michael Drain*^abc

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^a Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA
E-mail: cdrain@hunter.cuny.edu

^b Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA

^c Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

Abstract

A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.

Chemical Communications

Facile synthesis of chlorin bioconjugates by a series of click reactions†

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Facile synthesis of chlorin bioconjugates by a series of click reactions

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