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Issue 23, 2017
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Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

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Abstract

The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.

Graphical abstract: Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

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Article information


Submitted
10 Feb 2017
Accepted
03 Mar 2017
First published
03 Mar 2017

Chem. Commun., 2017,53, 3381-3384
Article type
Communication

Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

U. B. Rao Khandavilli, B. R. Bhogala, A. R. Maguire and S. E. Lawrence, Chem. Commun., 2017, 53, 3381
DOI: 10.1039/C7CC01091E

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