Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 23, 2017
Previous Article Next Article

Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

Author affiliations

Abstract

The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.

Graphical abstract: Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

Back to tab navigation

Supplementary files

Article information


Submitted
10 Feb 2017
Accepted
03 Mar 2017
First published
03 Mar 2017

Chem. Commun., 2017,53, 3381-3384
Article type
Communication

Symmetry assisted tuning of bending and brittle multi-component forms of probenecid

U. B. Rao Khandavilli, B. R. Bhogala, A. R. Maguire and S. E. Lawrence, Chem. Commun., 2017, 53, 3381
DOI: 10.1039/C7CC01091E

Social activity

Search articles by author

Spotlight

Advertisements