X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

H. Yang; D. R. Du Bois; J. W. Ziller; J. S. Nowick

doi:10.1039/C7CC00783C

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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore†

H. Yang,

^a D. R. Du Bois,^a J. W. Ziller^a and J. S. Nowick*^a

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* Corresponding authors

^a Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA
E-mail: jsnowick@uci.edu

Abstract

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

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DOI: https://doi.org/10.1039/C7CC00783C
Article type: Communication
Submitted: 30 Jan 2017
Accepted: 10 Feb 2017
First published: 13 Feb 2017

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Chem. Commun., 2017,53, 2772-2775

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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

H. Yang, D. R. Du Bois, J. W. Ziller and J. S. Nowick, Chem. Commun., 2017, 53, 2772 DOI: 10.1039/C7CC00783C

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Chemical Communications

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore†

Abstract

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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

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