Issue 21, 2017
From the journal:

Chemical Communications

Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel†

Erika Hasuike,‡ab   Aya Mizutani Akimoto,‡*a   Reiko Kuroda,*c   Ko Matsukawa,a   Yuki Hiruta, ORCID logo b   Hideko Kanazawab  and  Ryo Yoshida ORCID logo *a  

* Corresponding authors

a Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: akimoto@cross.t.u-tokyo.ac.jp, ryo@cross.t.u-toyo.ac.jp
Fax: +81-3-5841-7112
Tel: +81-3-5841-7112

b Faculty of Pharmacy, Keio University, Tokyo, Japan

c Research Institute for Science and Technology, Tokyo University of Science, Chiba, Japan

Abstract

The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.

Graphical abstract: Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

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Article information

DOI
https://doi.org/10.1039/C7CC00279C
Article type
Communication
Submitted
12 Jan 2017
Accepted
22 Feb 2017
First published
22 Feb 2017

Chem. Commun., 2017,53, 3142-3144

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Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

E. Hasuike, A. M. Akimoto, R. Kuroda, K. Matsukawa, Y. Hiruta, H. Kanazawa and R. Yoshida, Chem. Commun., 2017, 53, 3142 DOI: 10.1039/C7CC00279C

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