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Issue 30, 2017
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The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

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Abstract

Metalation of hen egg white lysozyme (HEWL) with organometallics was studied with physicochemical methods in solid state, solution and the gas phase. While metalation did not affect the crystal structure of HEWL significantly, protein destabilisation was detected in gas phase and solution.

Graphical abstract: The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

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Article information


Submitted
22 Dec 2016
Accepted
16 Mar 2017
First published
21 Mar 2017

Chem. Commun., 2017,53, 4246-4249
Article type
Communication

The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography

M. P. Sullivan, M. Groessl, S. M. Meier, R. L. Kingston, D. C. Goldstone and C. G. Hartinger, Chem. Commun., 2017, 53, 4246
DOI: 10.1039/C6CC10150J

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