Issue 15, 2017
From the journal:

Chemical Communications

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease†

Chung Ying Chan,a   Asif Noor,b   Catriona A. McLean,c   Paul S. Donnellyb  and  Peter J. Barnard ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia
E-mail: p.barnard@latrobe.edu.au

b School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia

c Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia

Abstract

A series of [Re(I)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)–amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

Graphical abstract: Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C6CC10066J
Article type
Communication
Submitted
19 Dec 2016
Accepted
17 Jan 2017
First published
17 Jan 2017

Chem. Commun., 2017,53, 2311-2314

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Rhenium(I) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

C. Y. Chan, A. Noor, C. A. McLean, P. S. Donnelly and P. J. Barnard, Chem. Commun., 2017, 53, 2311 DOI: 10.1039/C6CC10066J

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