PSMA-targeted contrast agents for intraoperative imaging of prostate cancer,

Kai Bao; Jeong Heon Lee; Homan Kang; G. Kate Park; Georges El Fakhri; Hak Soo Choi

doi:10.1039/C6CC09781B

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PSMA-targeted contrast agents for intraoperative imaging of prostate cancer†,‡

Kai Bao,^ab Jeong Heon Lee,^a Homan Kang,^a G. Kate Park,^a Georges El Fakhri^a and Hak Soo Choi

*^a

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* Corresponding authors

^a Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA 02114, USA
E-mail: hchoi12@mgh.harvard.edu
Fax: +1 617-643-2604
Tel: +1 617-726-5784

^b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

Abstract

Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the detection and treatment of prostate cancer. Near-infrared (NIR) fluorescence imaging enables highly sensitive, rapid, and non-radioactive imaging of PSMA, though specific targeting still remains a challenge because no optimized contrast agents exist.

This article is part of the themed collection: Biological optical imaging

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Article information

DOI: https://doi.org/10.1039/C6CC09781B
Article type: Communication
Submitted: 13 Dec 2016
Accepted: 09 Jan 2017
First published: 13 Jan 2017

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Chem. Commun., 2017,53, 1611-1614

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PSMA-targeted contrast agents for intraoperative imaging of prostate cancer,

K. Bao, J. H. Lee, H. Kang, G. K. Park, G. El Fakhri and H. S. Choi, Chem. Commun., 2017, 53, 1611 DOI: 10.1039/C6CC09781B

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Chemical Communications

PSMA-targeted contrast agents for intraoperative imaging of prostate cancer†,‡

Abstract

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PSMA-targeted contrast agents for intraoperative imaging of prostate cancer,

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