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Issue 6, 2017
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Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective

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Abstract

Herein is reported the mild and general coupling of amine/ether C(sp3)–H bonds with various kinds of C(sp2)–O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification.

Graphical abstract: Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective

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Article information


Submitted
06 Dec 2016
Accepted
23 Dec 2016
First published
06 Jan 2017

Chem. Commun., 2017,53, 1192-1195
Article type
Communication

Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective

Y. Gui, L. Liao, L. Sun, Z. Zhang, J. Ye, G. Shen, Z. Lu, W. Zhou and D. Yu, Chem. Commun., 2017, 53, 1192
DOI: 10.1039/C6CC09685A

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