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Issue 10, 2017
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Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

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Abstract

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Brønsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enantioselectivity.

Graphical abstract: Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

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Article information


Submitted
29 Nov 2016
Accepted
05 Jan 2017
First published
05 Jan 2017

Chem. Commun., 2017,53, 1704-1707
Article type
Communication

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

B. Song, C. Yu, Y. Ji, M. Chen and Y. Zhou, Chem. Commun., 2017, 53, 1704
DOI: 10.1039/C6CC09493G

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