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Issue 10, 2017
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Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

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Abstract

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Brønsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enantioselectivity.

Graphical abstract: Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

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Publication details

The article was received on 29 Nov 2016, accepted on 05 Jan 2017 and first published on 05 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09493G
Citation: Chem. Commun., 2017,53, 1704-1707
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    Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

    B. Song, C. Yu, Y. Ji, M. Chen and Y. Zhou, Chem. Commun., 2017, 53, 1704
    DOI: 10.1039/C6CC09493G

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