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Issue 23, 2017
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Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

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Abstract

We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(III) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.

Graphical abstract: Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

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Publication details

The article was received on 28 Nov 2016, accepted on 15 Feb 2017 and first published on 15 Feb 2017


Article type: Communication
DOI: 10.1039/C6CC09470H
Chem. Commun., 2017,53, 3303-3306

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    Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

    X. Tian, Y. Zhu, M. Zhang, L. Luo, J. Wu, H. Zhou, L. Guan, G. Battaglia and Y. Tian, Chem. Commun., 2017, 53, 3303
    DOI: 10.1039/C6CC09470H

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