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Issue 27, 2017
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One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

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Abstract

We developed a one-pot synthetic technique for alternating peptides. Central to this technique is a new, catalyst-free polymerization based on Ugi's 4CC reaction. The treatment of imines with the ambident molecules bearing both an isocyanide and a carboxylic acid afforded alternating peptides.

Graphical abstract: One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

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Article information


Submitted
24 Nov 2016
Accepted
12 Mar 2017
First published
13 Mar 2017

Chem. Commun., 2017,53, 3846-3849
Article type
Communication

One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

Y. Koyama and P. G. Gudeangadi, Chem. Commun., 2017, 53, 3846
DOI: 10.1039/C6CC09379E

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