Jump to main content
Jump to site search

Issue 7, 2017
Previous Article Next Article

Targeted combinational therapy inducing mitochondrial dysfunction

Author affiliations

Abstract

We report on a mitochondria-specific combinational theranostic agent, 1. This system contains a chlorambucil prodrug and an aggregation induced emission dye. In addition, compound 1 bears both an intracellular thiol-triggered moiety and a mitochondria targeting unit (triphenylphosphonium). Glutathione (GSH) is the most abundant thiol and its concentrations are significantly higher in a great number of cancer cell lines, compared to normal cells. The GSH-induced prodrug 1 upon activation releases chlorambucil and exhibits mitochondria targeted aggregation induced emission (AIE) fluorescence, resulting in cell apoptosis via the caspase pathway due to mitochondrial dysfunction.

Graphical abstract: Targeted combinational therapy inducing mitochondrial dysfunction

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Nov 2016, accepted on 22 Dec 2016 and first published on 22 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC08977A
Chem. Commun., 2017,53, 1281-1284

  •   Request permissions

    Targeted combinational therapy inducing mitochondrial dysfunction

    W. S. Shin, S. K. Park, P. Verwilst, S. Koo, J. H. Lee, S. Chi and J. S. Kim, Chem. Commun., 2017, 53, 1281
    DOI: 10.1039/C6CC08977A

Search articles by author

Spotlight

Advertisements