Sulfur dioxide prodrugs: triggered release of SO2via a click reaction

Abstract

Sulfur dioxide (SO₂) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H₂S. Herein we describe a series of SO₂ prodrugs that are activated for SO₂ release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.