Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells†
Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
- This article is part of the themed collections: Biological optical imaging and Most downloaded articles of 2017: Analytical Chemistry