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Issue 10, 2017
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Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

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Abstract

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Graphical abstract: Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

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Publication details

The article was received on 04 Nov 2016, accepted on 05 Jan 2017 and first published on 05 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08826K
Chem. Commun., 2017,53, 1607-1610

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    Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

    S. Lim, Md. M. Haque, D. Su, D. Kim, J. Lee, Y. Chang and Y. K. Kim, Chem. Commun., 2017, 53, 1607
    DOI: 10.1039/C6CC08826K

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