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Issue 9, 2017
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Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes

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Abstract

A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles.

Graphical abstract: Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes

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Publication details

The article was received on 27 Oct 2016, accepted on 03 Jan 2017 and first published on 03 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08640C
Citation: Chem. Commun., 2017,53, 1478-1481

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    Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes

    S. Premaletha, A. Ghosh, S. Joseph, S. R. Yetra and A. T. Biju, Chem. Commun., 2017, 53, 1478
    DOI: 10.1039/C6CC08640C

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