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Issue 3, 2017
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Polyoxometalates as artificial nucleases: hydrolytic cleavage of DNA promoted by a highly negatively charged ZrIV-substituted Keggin polyanion

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Abstract

A highly negatively charged binuclear ZrIV-substituted Keggin polyoxometalate [{α-PW11O39Zr(μ-OH)(H2O)}2]8− (ZrK 2 : 2) has been shown to promote the hydrolytic cleavage of phosphoester bonds in the supercoiled plasmid pUC19 DNA under physiological pH and temperature, giving relaxed and linear forms of pUC19 as hydrolysis products. The interaction between ZrK 2 : 2 and DNA was experimentally proven by circular dichroism (CD) spectroscopy and 31P diffusion ordered NMR spectroscopy.

Graphical abstract: Polyoxometalates as artificial nucleases: hydrolytic cleavage of DNA promoted by a highly negatively charged ZrIV-substituted Keggin polyanion

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Supplementary files

Article information


Submitted
24 Oct 2016
Accepted
09 Dec 2016
First published
09 Dec 2016

Chem. Commun., 2017,53, 617-620
Article type
Communication

Polyoxometalates as artificial nucleases: hydrolytic cleavage of DNA promoted by a highly negatively charged ZrIV-substituted Keggin polyanion

T. K. N. Luong, I. Govaerts, J. Robben, P. Shestakova and T. N. Parac-Vogt, Chem. Commun., 2017, 53, 617
DOI: 10.1039/C6CC08555E

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