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Issue 5, 2017
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A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

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Abstract

The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells.

Graphical abstract: A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

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Publication details

The article was received on 28 Sep 2016, accepted on 13 Dec 2016 and first published on 15 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC07879F
Chem. Commun., 2017,53, 945-948

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    A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

    R. Subiros-Funosas, L. Mendive-Tapia, J. Sot, J. D. Pound, N. Barth, Y. Varela, F. M. Goñi, M. Paterson, C. D. Gregory, F. Albericio, I. Dransfield, R. Lavilla and M. Vendrell, Chem. Commun., 2017, 53, 945
    DOI: 10.1039/C6CC07879F

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