Issue 1, 2018
From the journal:

Biomaterials Science

Bone-targeting poly(ethylene sodium phosphate)†

Yasuhiko Iwasaki, ORCID logo *ab   Atsushi Yokota,c   Akihisa Otaka, ORCID logo b   Naoyuki Inoue,a   Akane Yamaguchi,d   Toru Yoshitomi,d   Keitaro Yoshimotode  and  Masashi Neoc  

* Corresponding authors

a Department of Chemistry and Materials Engineering, Kansai University, 3-3-35, Yamate-cho, Suita-shi, Osaka 564-8680, Japan
E-mail: yasu.bmt@kansai-u.ac.jp

b ORDIST, Kansai University, 3-3-35, Yamate-cho, Suita-shi, Osaka 564-8680, Japan

c Department of Orthopedic Surgery, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, Japan

d Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro, Tokyo 153-8902, Japan

e JST, PRESTO, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan

Abstract

Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a promising polymer for bone-targeted therapies.

Graphical abstract: Bone-targeting poly(ethylene sodium phosphate)

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Article information

DOI
https://doi.org/10.1039/C7BM00930E
Article type
Communication
Submitted
12 Oct 2017
Accepted
17 Nov 2017
First published
21 Nov 2017

Biomater. Sci., 2018,6, 91-95

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Bone-targeting poly(ethylene sodium phosphate)

Y. Iwasaki, A. Yokota, A. Otaka, N. Inoue, A. Yamaguchi, T. Yoshitomi, K. Yoshimoto and M. Neo, Biomater. Sci., 2018, 6, 91 DOI: 10.1039/C7BM00930E

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