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Issue 12, 2017
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A new developing class of gene delivery: messenger RNA-based therapeutics

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Abstract

Gene therapy has long been held as having the potential to become a front line treatment for various genetic disorders. However, the direct delivery of nucleic acids to correct a genetic disorder has numerous limitations owing to the inability of naked nucleic acids (DNA and RNA) to traverse the cell membrane. Recently, messenger RNA (mRNA) based delivery has become a more attractive alternative to DNA due to the relatively easier transfection process, higher efficiency and safety profile. As with all gene therapies, the central challenge that remains is the efficient delivery of nucleic acids intracellularly. This review presents the recent progress in mRNA delivery, focusing on comparing the advantages and limitations of non-viral based delivery vectors.

Graphical abstract: A new developing class of gene delivery: messenger RNA-based therapeutics

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Article information


Submitted
06 Aug 2017
Accepted
29 Sep 2017
First published
02 Oct 2017

Biomater. Sci., 2017,5, 2381-2392
Article type
Review Article

A new developing class of gene delivery: messenger RNA-based therapeutics

Z. Meng, J. O'Keeffe-Ahern, J. Lyu, L. Pierucci, D. Zhou and W. Wang, Biomater. Sci., 2017, 5, 2381
DOI: 10.1039/C7BM00712D

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