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Issue 10, 2017
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Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide

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Abstract

We report the design and characterization of a peptide that assembles as β-hairpins and forms hydrogels under physiological conditions. These hydrogels formed both in the absence and presence of several metal ions and displayed characteristic sheer-thinning properties. In particular, in the presence of Zn2+, we observed a novel hydrogel that proceeded via an intermolecular metal-coordination mechanism – intermolecular assembly that was previously reported instead to promote amyloid type aggregates.

Graphical abstract: Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide

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Submitted
12 Jun 2017
Accepted
23 Aug 2017
First published
24 Aug 2017

Biomater. Sci., 2017,5, 1993-1997
Article type
Communication

Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide

L. M. De Leon-Rodriguez, Y. Hemar, A. K. Mitra and M. A. Brimble, Biomater. Sci., 2017, 5, 1993
DOI: 10.1039/C7BM00512A

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