Issue 4, 2017

Microvalve-based bioprinting – process, bio-inks and applications


Bioprinting is an emerging research field that has attracted tremendous attention for various applications; it offers a highly automated, advanced manufacturing platform for the fabrication of complex bioengineered constructs. Different bio-inks comprising multiple types of printable biomaterials and cells are utilized during the bioprinting process to improve the homology to native tissues and/or organs in a highly reproducible manner. This paper, presenting a first-time comprehensive yet succinct review of microvalve-based bioprinting, provides an in-depth analysis and comparison of different drop-on-demand bioprinting systems and highlights the important considerations for microvalve-based bioprinting systems. This review paper reports a detailed analysis of its printing process, bio-ink properties and cellular components on the printing outcomes. Lastly, this review highlights the significance of drop-on-demand bioprinting for various applications such as high-throughput screening, fundamental cell biology research, in situ bioprinting and fabrication of in vitro tissue constructs and also presents future directions to transform the microvalve-based bioprinting technology into imperative tools for tissue engineering and regenerative medicine.

Graphical abstract: Microvalve-based bioprinting – process, bio-inks and applications

Article information

Article type
Review Article
27 Nov 2016
22 Jan 2017
First published
15 Feb 2017
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2017,5, 632-647

Microvalve-based bioprinting – process, bio-inks and applications

W. L. Ng, J. M. Lee, W. Y. Yeong and M. Win Naing, Biomater. Sci., 2017, 5, 632 DOI: 10.1039/C6BM00861E

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