Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 34, 2017
Previous Article Next Article

Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

Author affiliations

Abstract

The synthesis of ‘designer drugs’ and derivatives has recently proliferated in the illicit drug market. For forensic drug analysis, conventional sample preparation and chromatographic separation techniques may be laborious and time-consuming. The characterization of these controlled substances may benefit from more rapid and high-throughput techniques. DMS (Differential Mobility Spectrometry), a variant of ion mobility spectrometry, is an emerging technology for post-ionization differentiation and filtration of isobaric interferences. When used before mass spectrometric analysis, DMS provides ion filtration on the order of milliseconds. Electro-sprayed DMS-MS studies have been implemented by various researchers for forensic studies. A complication associated with the introduction of sprayed ionization techniques is that the mechanism of solvent–ion interactions in DMS separation still remains unclear. In this study, we employ DART ionization as a robust solvent-less ionization technique coupled to DMS to demonstrate their combined utility and compatibility. Herein, amphetamine and derivatives were analyzed suggesting a promising alternative for rapid separation and characterization of new psychoactive substances.

Graphical abstract: Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

Back to tab navigation

Supplementary files

Article information


Submitted
05 Apr 2017
Accepted
18 Jun 2017
First published
19 Jun 2017

Anal. Methods, 2017,9, 5044-5051
Article type
Paper

Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

I. Ayodeji, T. Vazquez, R. Bailey and T. Evans-Nguyen, Anal. Methods, 2017, 9, 5044
DOI: 10.1039/C7AY00892A

Social activity

Search articles by author

Spotlight

Advertisements