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Issue 7, 2017
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NMR-based metabolomics strategies: plants, animals and humans

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Abstract

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical platform employed to address a diversity of issues of research such as in understanding chemical reaction mechanisms and chemical kinetics, and characterization and elucidation of small and macromolecules, among many others. In the last few decades and with the advancement of biotechnology, NMR has been widely employed in metabolomics where it has greatly contributed to the agricultural, veterinary, medicinal and pharmacological fields in the search for biomarkers of diseases. This Tutorial Review addresses the principal steps (sample preparation, acquisition and processing of spectra, data analysis and biomarker discovery) and methodologies used in NMR-based metabolomics applied for pointing to key metabolites of diseases.

Graphical abstract: NMR-based metabolomics strategies: plants, animals and humans

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Publication details

The article was received on 15 Nov 2016, accepted on 03 Jan 2017 and first published on 04 Jan 2017


Article type: Tutorial Review
DOI: 10.1039/C6AY03102A
Anal. Methods, 2017,9, 1078-1096

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    NMR-based metabolomics strategies: plants, animals and humans

    J. G. M. Pontes, A. J. M. Brasil, G. C. F. Cruz, R. N. de Souza and L. Tasic, Anal. Methods, 2017, 9, 1078
    DOI: 10.1039/C6AY03102A

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