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Issue 9, 2017
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Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

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Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

Graphical abstract: Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

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Supplementary files

Article information


Submitted
13 Jan 2017
Accepted
11 Mar 2017
First published
13 Mar 2017

Analyst, 2017,142, 1429-1433
Article type
Communication

Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

D. E. Korenchan, C. Taglang, C. von Morze, J. E. Blecha, J. W. Gordon, R. Sriram, P. E. Z. Larson, D. B. Vigneron, H. F. VanBrocklin, J. Kurhanewicz, D. M. Wilson and R. R. Flavell, Analyst, 2017, 142, 1429 DOI: 10.1039/C7AN00076F

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