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Issue 27, 2017
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Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

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Abstract

Conjugated polymers (CPs) with intensive near-infrared (NIR) absorption and high photothermal conversion efficiency (PCE) have emerged as a new generation of photothermal therapy (PTT) and photoacoustic imaging (PAI) agents for cancer therapy. PTT + chemotherapy has been identified as a powerful modality to offer synergistic effects in the destruction and monitoring of cancer tissues. In this study, diketopyrrolopyrrole-based polymers (DPP) were designed through a combination of donor–acceptor moieties. Then, doxorubicin (DOX) and DPP were co-encapsulated in tocopheryl polyethylene-glycol-succinate-cholesterol (TPGS-CHO) copolymers to build a combined theranostic system for tumor treatment. These combined NPs with high PCE (∼50%) and strong (NIR) absorption exhibit excellent real-time photoacoustic imaging detection and synergistic cancer inhibition.

Graphical abstract: Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

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Supplementary files

Article information


Submitted
09 May 2017
Accepted
15 Jun 2017
First published
15 Jun 2017

J. Mater. Chem. B, 2017,5, 5479-5487
Article type
Paper

Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

Y. Cao, Y. Wu, G. Wang, J. Yi, C. Yu, Y. Huang, L. Sun, Y. Bao and Y. Li, J. Mater. Chem. B, 2017, 5, 5479
DOI: 10.1039/C7TB01264K

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