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Issue 29, 2017
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PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

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Abstract

Three ruthenium(II) phthalocyanines functionalized at their axial positions with 4–12 PEG chains bearing hydroxy, amino and ether terminal groups were synthesized and studied as PDT agents against bladder cancer cells. All three dyes displayed high singlet oxygen generation quantum yields in DMSO (ΦΔ = 0.76). The water-soluble Ru(L3)2Pc also shows high singlet oxygen quantum yields (ΦΔ = 0.48) in neat water. In vitro studies show that these complexes are accumulated in bladder cancer cells, are nontoxic PSs per se, and have high phototoxic efficiency.

Graphical abstract: PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

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Supplementary files

Article information


Submitted
06 Apr 2017
Accepted
22 Jun 2017
First published
22 Jun 2017

J. Mater. Chem. B, 2017,5, 5862-5869
Article type
Paper

PEG-containing ruthenium phthalocyanines as photosensitizers for photodynamic therapy: synthesis, characterization and in vitro evaluation

J. Teles Ferreira, J. Pina, C. Alberto Fontes Ribeiro, R. Fernandes, J. P. C. Tomé, M. S. Rodríguez-Morgade and T. Torres, J. Mater. Chem. B, 2017, 5, 5862
DOI: 10.1039/C7TB00958E

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