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Issue 20, 2017
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Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

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Abstract

Stimuli-responsive theranostic platforms are highly desirable for efficient cancer treatment because of their improved specificity and sensitivity. In this work, we report a manganese-iron layered double hydroxide (MnFe-LDH) for the first time and demonstrate that it can serve as a pH-responsive nanoplatform for cancer theranostics. The MnFe-LDH can respond to the acidic microenvironment of solid tumors to release paramagnetic Mn2+ and Fe3+ ions, resulting in great enhancement of the T1 MRI contrast of the tumor area. In addition, the layered structure enables MnFe-LDH to effectively deliver chemotherapeutic drugs in a pH-controlled manner, and therefore it can simultaneously inhibit the growth of solid tumors. We believe that this novel MnFe-LDH with pH-responsive property holds great promise in cancer theranostic applications.

Graphical abstract: Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

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Article information


Submitted
22 Mar 2017
Accepted
06 May 2017
First published
08 May 2017

J. Mater. Chem. B, 2017,5, 3629-3633
Article type
Communication

Manganese-iron layered double hydroxide: a theranostic nanoplatform with pH-responsive MRI contrast enhancement and drug release

G. Huang, K. Zhang, S. Chen, S. Li, L. Wang, L. Wang, R. Liu, J. Gao and H. Yang, J. Mater. Chem. B, 2017, 5, 3629
DOI: 10.1039/C7TB00794A

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