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Issue 3, 2017
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Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

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Abstract

Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications. This strategy is found to be bio-inspired, straightforward, and environmentally benign. It can produce inorganic/metal NPs with good stability, excellent biocompatibility, high water solubility, and rich surface functional groups for further bioconjunction. In this review, we provide a summary of the previously reported proteins/peptides as biotemplates involved in biomimetic mineralization synthesis, and categorize the obtained inorganic NPs ranging from metal nanoclusters (MNCs), quantum dots (QDs), gadolinium derivatives, and metal sulfide nanoparticles (MSNPs) with an emphasis on the recent progress in their use in biomedical applications, including bio-sensing, ion detection, bio-labeling, in vivo imaging and therapy. In the end, the challenges and future outlook in this emerging area are also discussed.

Graphical abstract: Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

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Article information


Submitted
06 Sep 2016
Accepted
08 Nov 2016
First published
08 Nov 2016

J. Mater. Chem. B, 2017,5, 401-417
Article type
Review Article

Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

W. Yang, W. Guo, J. Chang and B. Zhang, J. Mater. Chem. B, 2017, 5, 401
DOI: 10.1039/C6TB02308H

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