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Issue 16, 2017
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Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties

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Abstract

Multiresponsive and biocompatible self-healing ε-PL/A-Pul/BPEI hydrogels were prepared in aqueous solution by Schiff base reaction with aldehyded pullulan (A-Pul), ε-poly-L-lysine (ε-PL) and branched polyethyleneimine (BPEI) as materials. The imine bonds were rapidly cross-linked into a hydrogel network within 80 s. Scanning electron microscopy images showed that the hydrogels exhibited a cross-linked structure with the average pore size from 58 to 82 μm. Rheology tests indicated that the hydrogels maintained good mechanical properties. Water contact angles and swelling studies suggested that the hydrogels could swell in water, with a max swell ratio of 1559%, and pH and temperature had an influence on the equilibrium swelling ratio. The hydrogels could be injected either before or after gelation, and they displayed a self-healing process in ddH2O at room temperature based on the dynamic uncoupling and recoupling of the imine bonds. The MTT assays implied that the hydrogels were non-cytotoxic on mice bone marrow mesenchymal stem cells. Therefore, the hydrogels showed potential application in biomedical fields, and consequently further work was performed using the self-healing hydrogels as drug carriers in in vitro/vivo antitumor studies.

Graphical abstract: Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties

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Publication details

The article was received on 20 Feb 2017, accepted on 20 Mar 2017 and first published on 21 Mar 2017


Article type: Paper
DOI: 10.1039/C7SM00350A
Soft Matter, 2017,13, 3003-3012

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    Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties

    C. Cheng, X. Zhang, Y. Meng, Z. Zhang, J. Chen and Q. Zhang, Soft Matter, 2017, 13, 3003
    DOI: 10.1039/C7SM00350A

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