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Issue 12, 2017
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Ruthenium(ii)-catalyzed olefination via carbonyl reductive cross-coupling

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Abstract

Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(II) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in either an intermolecular or intramolecular fashion. Moreover, this chemistry accommodates a variety of substrates, proceeds under mild reaction conditions with good functional group tolerance, and generates stoichiometric benign byproducts. Importantly, the coexistence of KOtBu and bidentate phosphine dmpe is vital to this transformation.

Graphical abstract: Ruthenium(ii)-catalyzed olefination via carbonyl reductive cross-coupling

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Article information


Submitted
26 Sep 2017
Accepted
08 Oct 2017
First published
09 Oct 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 8193-8197
Article type
Edge Article

Ruthenium(II)-catalyzed olefination via carbonyl reductive cross-coupling

W. Wei, X. Dai, H. Wang, C. Li, X. Yang and C. Li, Chem. Sci., 2017, 8, 8193 DOI: 10.1039/C7SC04207H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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