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Issue 10, 2017
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Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

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Abstract

We herein describe a palladium-catalyzed formal aromaticity transfer coupling reaction between phenols and pyrrolidines or indolines to generate the corresponding N-cyclohexyl pyrroles or indoles. In this transformation, the aromaticity of phenols is formally passed on to the pyrrolidine or indoline units. Substituted phenols thus can serve as latent cyclohexyl equivalents for the fast construction of various N-cyclohexyl pyrroles and indoles.

Graphical abstract: Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

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Supplementary files

Article information


Submitted
08 Jun 2017
Accepted
09 Aug 2017
First published
10 Aug 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 6954-6958
Article type
Edge Article

Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

Z. Qiu, J. Li and C. Li, Chem. Sci., 2017, 8, 6954 DOI: 10.1039/C7SC02578E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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