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Issue 1, 2017
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A biocatalytic approach towards the stereoselective synthesis of protected inositols

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Abstract

A biocatalytic flow system utilising Trypanosoma bruceiL-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before.

Graphical abstract: A biocatalytic approach towards the stereoselective synthesis of protected inositols

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Publication details

The article was received on 27 Sep 2016, accepted on 12 Dec 2016 and first published on 12 Dec 2016


Article type: Paper
DOI: 10.1039/C6RE00175K
React. Chem. Eng., 2017,2, 44-49

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    A biocatalytic approach towards the stereoselective synthesis of protected inositols

    L. H. Sayer, G. J. Florence and T. K. Smith, React. Chem. Eng., 2017, 2, 44
    DOI: 10.1039/C6RE00175K

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